منابع مشابه
THE ROLE OF SR AND SR‐RELATED PROTEINS IN pre‐mRNA SPLICING
Pre‐mRNA splicing requires the activities of small nuclear ribonucleoproteins and other essential splicing factors. Among these are members of the SR protein family and SR‐related proteins, which are integrally involved in regulating exon recognition, spliceosomal assembly, and spliceosomal re‐arrangements to promote intron excision. This chapter will focus on the discovery of SR proteins and S...
متن کاملPervasive unproductive splicing of SR proteins associated with ultraconserved elements
SR proteins play critical roles in the regulation of pre-mRNA splicing. We show that most human SR protein genes are themselves alternatively spliced, and their alternative splice forms are often targets of a degradation pathway known as nonsense-mediated mRNA decay (NMD). By mining EST databases for sequences corresponding to the 11 human SR protein genes, we have identified premature stop (no...
متن کاملSR proteins are ‘locators’ of the RNA splicing machinery
For those of us used to hearing with our ears, it is difficult to imagine how the fish or amphibian perceives its environment on the basis of information from the lateral line sensory system. The lateral line system detects vibrations in the water, a process that has been termed ‘svenning’ — after Sven Dijkgraaf (1908–1995), a founder figure in lateral line research — and is neatly summarised i...
متن کاملRegulation of splicing-associated SR proteins by HPV-16.
HPV-16 (human papillomavirus type 16) is a small dsDNA (double-stranded DNA) virus which infects mucosal epithelial tissue of the cervix. Epithelial tissue is composed of a basal layer of cells, capable of division, and a number of suprabasal layers, wherein the cells become more differentiated the closer to the surface of the epithelium they become. Expression of viral proteins is dependent up...
متن کاملSR proteins: a conserved family of pre-mRNA splicing factors.
We demonstrate that four different proteins from calf thymus are able to restore splicing in the same splicing-deficient extract using several different pre-mRNA substrates. These proteins are members of a conserved family of proteins recognized by a monoclonal antibody that binds to active sites of RNA polymerase II transcription. We purified this family of nuclear phosphoproteins to apparent ...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1996
ISSN: 0890-9369
DOI: 10.1101/gad.10.13.1569